Data privacy is a critical challenge in modern medical workflows as the adoption of electronic patient records has grown rapidly. Stringent data protection regulations limit access to clinical records for training and integrating machine learning models that have shown promise in improving diagnostic accuracy and personalized care outcomes. Synthetic data offers a promising alternative; however, current generative models either struggle with time-series data or lack formal privacy guaranties. In this paper, we enhance a state-of-the-art time-series generative model to better handle longitudinal clinical data while incorporating quantifiable privacy safeguards. Using real data from chronic kidney disease and ICU patients, we evaluate our method through statistical tests, a Train-on-Synthetic-Test-on-Real (TSTR) setup, and expert clinical review. Our non-private model (Augmented TimeGAN) outperforms transformer- and flow-based models on statistical metrics in several datasets, while our private model (DP-TimeGAN) maintains a mean authenticity of 0.778 on the CKD dataset, outperforming existing state-of-the-art models on the privacy-utility frontier. Both models achieve performance comparable to real data in clinician evaluations, providing robust input data necessary for developing models for complex chronic conditions without compromising data privacy.

Deterministic Lateral Displacement (DLD) devices are widely used in microfluidics for label-free, size-based separation of particles and cells, with particular promise in isolating circulating tumor cells (CTCs) for early cancer diagnostics. This study focuses on the optimization of DLD design parameters, such as row shift fraction, post size, and gap distance, to enhance the selective isolation of lung cancer cells based on their physical properties. To overcome the challenges of rare CTC detection and reduce reliance on computationally intensive simulations, machine learning models including gradient boosting, k-nearest neighbors, random forest, and multilayer perceptron (MLP) regressors are employed. Trained on a large, numerically validated dataset, these models predict particle trajectories and identify optimal device configurations, enabling high-throughput and cost-effective DLD design. Beyond trajectory prediction, the models aid in isolating critical design variables, offering a systematic, data-driven framework for automated DLD optimization. This integrative approach advances the development of scalable and precise microfluidic systems for cancer diagnostics, contributing to the broader goals of early detection and personalized medicine.

Generative artificial intelligence is developing rapidly, impacting humans' interaction with information and digital media. It is increasingly used to create deceptively realistic misinformation, so lawmakers have imposed regulations requiring the disclosure of AI-generated content. However, only little is known about whether these labels reduce the risks of AI-generated misinformation. Our work addresses this research gap. Focusing on AI-generated images, we study the implications of labels, including the possibility of mislabeling. Assuming that simplicity, transparency, and trust are likely to impact the successful adoption of such labels, we first qualitatively explore users' opinions and expectations of AI labeling using five focus groups. Second, we conduct a pre-registered online survey with over 1300 U.S. and EU participants to quantitatively assess the effect of AI labels on users' ability to recognize misinformation containing either human-made or AI-generated images. Our focus groups illustrate that, while participants have concerns about the practical implementation of labeling, they consider it helpful in identifying AI-generated images and avoiding deception. However, considering security benefits, our survey revealed an ambiguous picture, suggesting that users might over-rely on labels. While inaccurate claims supported by labeled AI-generated images were rated less credible than those with unlabeled AI-images, the belief in accurate claims also decreased when accompanied by a labeled AI-generated image. Moreover, we find the undesired side effect that human-made images conveying inaccurate claims were perceived as more credible in the presence of labels.

What happens when a rideshare driver is suddenly locked out of the platform connecting them to riders, wages, and daily work? Deactivation-the abrupt removal of gig workers' platform access-typically occurs through arbitrary AI and algorithmic decisions with little explanation or recourse. This represents one of the most severe forms of algorithmic control and often devastates workers' financial stability. Recent U.S. state policies now mandate appeals processes and recovering compensation during the period of wrongful deactivation based on past earnings. Yet, labor organizers still lack effective tools to support these complex, error-prone workflows. We designed FareShare, a computational tool automating lost wage estimation for deactivated drivers, through a 6 month partnership with the State of Washington's largest rideshare labor union. Over the following 3 months, our field deployment of FareShare registered 178 account signups. We observed that the tool could reduce lost wage calculation time by over 95%, eliminate manual data entry errors, and enable legal teams to generate arbitration-ready reports more efficiently. Beyond these gains, the deployment also surfaced important socio-technical challenges around trust, consent, and tool adoption in high-stakes labor contexts.

Accurate dynamic modeling is critical for autonomous racing vehicles, especially during high-speed and agile maneuvers where precise motion prediction is essential for safety. Traditional parameter estimation methods face limitations such as reliance on initial guesses, labor-intensive fitting procedures, and complex testing setups. On the other hand, purely data-driven machine learning methods struggle to capture inherent physical constraints and typically require large datasets for optimal performance. To address these challenges, this paper introduces the Fine-Tuning Hybrid Dynamics (FTHD) method, which integrates supervised and unsupervised Physics-Informed Neural Networks (PINNs), combining physics-based modeling with data-driven techniques. FTHD fine-tunes a pre-trained Deep Dynamics Model (DDM) using a smaller training dataset, delivering superior performance compared to state-of-the-art methods such as the Deep Pacejka Model (DPM) and outperforming the original DDM. Furthermore, an Extended Kalman Filter (EKF) is embedded within FTHD (EKF-FTHD) to effectively manage noisy real-world data, ensuring accurate denoising while preserving the vehicle's essential physical characteristics. The proposed FTHD framework is validated through scaled simulations using the BayesRace Physics-based Simulator and full-scale real-world experiments from the Indy Autonomous Challenge. Results demonstrate that the hybrid approach significantly improves parameter estimation accuracy, even with reduced data, and outperforms existing models. EKF-FTHD enhances robustness by denoising real-world data while maintaining physical insights, representing a notable advancement in vehicle dynamics modeling for high-speed autonomous racing.

We explore the application of machine learning algorithms to predict the suitability of Russet potato clones for advancement in breeding trials. Leveraging data from manually collected trials in the state of Oregon, we investigate the potential of a wide variety of state-of-the-art binary classification models. We conduct a comprehensive analysis of the dataset that includes preprocessing, feature engineering, and imputation to address missing values. We focus on several key metrics such as accuracy, F1-score, and Matthews correlation coefficient (MCC) for model evaluation. The top-performing models, namely the multi-layer perceptron (MLPC), histogram-based gradient boosting classifier (HGBC), and a support vector machine (SVC), demonstrate consistent and significant results. Variable selection further enhances model performance and identifies influential features in predicting trial outcomes. The findings emphasize the potential of machine learning in streamlining the selection process for potato varieties, offering benefits such as increased efficiency, substantial cost savings, and judicious resource utilization. Our study contributes insights into precision agriculture and showcases the relevance of advanced technologies for informed decision-making in breeding programs.

With the advent of the Post-Moore era, the scientific community is faced with the challenge of addressing the demands of current data-intensive machine learning applications, which are the cornerstone of urgent analytics in distributed computing. Quantum machine learning could be a solution for the increasing demand of urgent analytics, providing potential theoretical speedups and increased space efficiency. However, challenges such as (1) the encoding of data from the classical to the quantum domain, (2) hyperparameter tuning, and (3) the integration of quantum hardware into a distributed computing continuum limit the adoption of quantum machine learning for urgent analytics. In this work, we investigate the use of Edge computing for the integration of quantum machine learning into a distributed computing continuum, identifying the main challenges and possible solutions.

Before 2020, the way occupants utilized the built environment had been changing slowly towards scenarios in which occupants have more choice and flexibility in where and how they work. The global COVID-19 pandemic accelerated this phenomenon rapidly through lockdowns and hybrid work arrangements. Many occupants and employers are considering keeping some of these flexibility-based strategies due to their benefits and cost impacts. This paper simulates various scenarios related to the operational technologies and policies of a real-world campus using a district-scale City Energy Analyst (CEA) model that is calibrated with measured energy and occupancy profiles extracted from WiFi data. These scenarios demonstrate the energy impact of ramping building operations up and down more rapidly and effectively to the flex-based work strategies that may solidify. The scenarios show a 4-12% decrease in space cooling demand due to occupant absenteeism if centralized building system operation is in place, but as high as 21-68% if occupancy-driven building controls are implemented. The paper discusses technologies and strategies that are important in this paradigm shift of operations.

In their search for new disease-fighting medicines, drug makers have long employed a laborious trial-and-error process to identify the right compounds. But what if artificial intelligence could predict the makeup of a new drug molecule the way Google figures out what you're searching for, or email programs anticipate your replies--like "Got it, thanks"? That's the aim of a new approach that uses an AI technique known as natural language processing--the same technology that enables OpenAI's ChatGPT to generate human-like responses--to analyze and synthesize proteins, which are the building blocks of life and of many drugs. The approach exploits the fact that biological codes have something in common with search queries and email texts: Both are represented by a series of letters. A look at how innovation and technology are transforming the way we live, work and play.

We present a masked vision-language transformer (MVLT) for fashion-specific multi-modal representation. Technically, we simply utilize vision transformer architecture for replacing the BERT in the pre-training model, making MVLT the first end-to-end framework for the fashion domain. Besides, we designed masked image reconstruction (MIR) for a fine-grained understanding of fashion. MVLT is an extensible and convenient architecture that admits raw multi-modal inputs without extra pre-processing models (e.g., ResNet), implicitly modeling the vision-language alignments. More importantly, MVLT can easily generalize to various matching and generative tasks. Experimental results show obvious improvements in retrieval (rank@5: 17%) and recognition (accuracy: 3%) tasks over the Fashion-Gen 2018 winner Kaleido-BERT. Code is made available at https://github.com/GewelsJI/MVLT.